Lesions that disappear and reappear do not automatically result in PD unless

• Other criteria are also met (new lesions, increase in the sum of longest diameters ≥ 20%) OR
• CR (overall) was definitively (*) assigned at the previous assessment. In this scenario, the reappearance of any malignant lesion results in PD.

(*) It is recommended that CR in previous cycle is confirmed – lesions may have in fact always been present but have been indistinct.  In such cases, PR may be appropriate for both assessments