Group: Target lesions

Coalesced lesions

When lesions coalesce, forming a conglomerate, a plane between them may be maintained that would aid in obtaining maximal diameter measurements of each individual lesion. If the lesions have truly coalesced such that they are no longer separable, the vector of the longest diameter in this instance should be the maximal longest diameter for the

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“Paired” organs

Questions often arise concerning the rule of selecting maximum 2 target lesions per organ, when it comes to paired organs (i.e. lung, kidney, ovaries, lymph nodes). In our analyses, ‘lung’, ‘kidney’, ‘ovaries’, ‘lymph nodes’ etc are considered as 1 organ, irrespective of the number of parts they may be made up of. Of note, if

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The definition of SD: a clarification

In the main article on page 233 the definition of SD is written as “Neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD, taking as reference the smallest sum diameters while on study.” It should be read as: “Neither sufficient shrinkage (compared to baseline) to qualify for PR nor sufficient increase

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